Trends in Biochemical Sciences
ForumDo All Roads Lead to Rome in G-Protein Activation?
Section snippets
Activation of G-Protein by GPCR and Non-GPCR GEFs
From the first atomic resolution structure of a GPCR–G-protein complex (β2 adrenergic receptor with Gs) reported in 2011 [1] and other holocomplex structures reported later (e.g., [11]), the most striking conformational rearrangement observed is a large separation of the Ras-like and helical domains of Gα. Such interdomain separation does not seem to be the principal trigger for nucleotide release, but rather, a sequel to allosteric mechanisms that trigger the release [4]; it facilitates the
Acknowledgments
The authors wish to apologize for not citing many important publications on this topic due to the limit of references allowed. P.G. is supported by NIH grants CA238042, AI141630, CA100768, and CA160911, and M.G-M. is supported by NIH grants GM108733, GM130120, GM136132, and MH118745.
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