The establishment of neuronal and glial networks in the brain depends on the activities of neural progenitors, which are influenced by cell-intrinsic mechanisms, interactions with the local microenvironment and long-range signaling. Progress in neuroscience has helped identify key factors in CNS development. In parallel, studies in recent years have increased our understanding of molecular and cellular factors in the development and growth of primary brain tumors. To thrive, glioma cells exploit pathways that are active in normal CNS progenitor cells, as well as in normal neurotransmitter signaling. Furthermore, tumor cells of incurable gliomas integrate into communicating multicellular networks, where they are interconnected through neurite-like cellular protrusions. In this Review, we discuss evidence that CNS development, organization and function share a number of common features with glioma progression and malignancy. These include mechanisms used by cells to proliferate and migrate, interact with their microenvironment and integrate into multicellular networks. The emerging intersections between the fields of neuroscience and neuro-oncology considered in this review point to new research directions and novel therapeutic opportunities.

中文翻译：

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神经科学与神经胶质瘤生物学之间的新兴交叉点。

大脑中神经元和神经胶质网络的建立取决于神经祖细胞的活动，这些活动受到细胞内在机制、与局部微环境的相互作用和远程信号传导的影响。神经科学的进步有助于确定中枢神经系统发育的关键因素。与此同时，近年来的研究增加了我们对原发性脑肿瘤发展和生长中的分子和细胞因素的理解。为了茁壮成长，神经胶质瘤细胞利用在正常 CNS 祖细胞以及正常神经递质信号传导中活跃的途径。此外，无法治愈的神经胶质瘤的肿瘤细胞整合到通讯多细胞网络中，它们通过神经突样细胞突起相互连接。在这篇综述中，我们讨论了中枢神经系统发育的证据，组织和功能与胶质瘤进展和恶性肿瘤具有许多共同特征。这些包括细胞用于增殖和迁移、与其微环境相互作用以及整合到多细胞网络中的机制。本综述中考虑的神经科学和神经肿瘤学领域之间新兴的交叉点指向了新的研究方向和新的治疗机会。