B cells in autoimmune and neurodegenerative central nervous system diseases.,Nature Reviews Neuroscience

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B cells in autoimmune and neurodegenerative central nervous system diseases.
Nature Reviews Neuroscience ( IF 28.7 ) Pub Date : 2019-11-11 , DOI: 10.1038/s41583-019-0233-2
Joseph J Sabatino _{1,

2} , Anne-Katrin Pröbstel _{1,

2,

3} , Scott S Zamvil _{1,

2,

4}

Affiliation

B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytokines and secretion of anti-inflammatory cytokines that limit immune responses. B cells can contribute to CNS disease either through their actions in the periphery (meaning that they have an 'outside-in' effect on CNS immunopathology) or following their compartmentalization within the CNS. The success of B cell-depleting therapy in patients with multiple sclerosis and CNS diseases with an autoantibody component, such as neuromyelitis optica spectrum disorder and autoimmune encephalitides, has underscored the role of B cells in both cellular and humoral-mediated CNS conditions. Emerging evidence suggests B cells also contribute to the pathogenesis of neurodegenerative diseases, including Alzheimer disease and Parkinson disease. Advancing our understanding of the role of B cells in neuroinflammatory and neurodegenerative diseases could lead to novel therapeutic approaches.

中文翻译：

自身免疫和神经退行性中枢神经系统疾病中的 B 细胞。

B 细胞是适应性免疫系统的重要组成部分，在几种中枢神经系统 (CNS) 疾病的发病机制中具有重要作用。除了产生抗体外，B 细胞还执行其他功能，包括向 T 细胞呈递抗原、产生促炎细胞因子和分泌限制免疫反应的抗炎细胞因子。B 细胞可以通过其在外周的作用（意味着它们对 CNS 免疫病理学具有“由外而内”的影响）或在 CNS 内的区室化之后促成 CNS 疾病。B 细胞消耗疗法在患有多发性硬化症和具有自身抗体成分的中枢神经系统疾病（如视神经脊髓炎谱系障碍和自身免疫性脑炎）患者中的成功，强调了 B 细胞在细胞和体液介导的中枢神经系统疾病中的作用。新出现的证据表明，B 细胞也有助于神经退行性疾病的发病机制，包括阿尔茨海默病和帕金森病。促进我们对 B 细胞在神经炎症和神经退行性疾病中的作用的理解可能会导致新的治疗方法。

更新日期：2019-11-11

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