Senescence is engaged in response to oncogenes to suppress proliferation. Cancers rewire metabolism to facilitate proliferation; however, it is not well appreciated how this enables senescence bypass. Recent work by Buj et al. demonstrates that loss of the tumor suppressor p16 engages a mTORC1-dependent increase in nucleotide pools to override senescence.

中文翻译：

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运行光：核苷酸代谢驱动绕过癌症衰老。

衰老参与对癌基因的反应以抑制增殖。癌症重新布线以促进增殖；然而，目前尚不清楚这如何实现衰老旁路。Buj 等人的最新工作。表明肿瘤抑制因子 p16 的缺失会导致核苷酸库依赖于 mTORC1 的增加来克服衰老。