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Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer.
Trends in Biochemical Sciences ( IF 11.6 ) Pub Date : 2019-11-04 , DOI: 10.1016/j.tibs.2019.10.007
Christopher J Halbrook 1 , Daniel R Wahl 2 , Costas A Lyssiotis 3
Affiliation  

Senescence is engaged in response to oncogenes to suppress proliferation. Cancers rewire metabolism to facilitate proliferation; however, it is not well appreciated how this enables senescence bypass. Recent work by Buj et al. demonstrates that loss of the tumor suppressor p16 engages a mTORC1-dependent increase in nucleotide pools to override senescence.

中文翻译:

运行光:核苷酸代谢驱动绕过癌症衰老。

衰老参与对癌基因的反应以抑制增殖。癌症重新布线以促进增殖;然而,目前尚不清楚这如何实现衰老旁路。Buj 等人的最新工作。表明肿瘤抑制因子 p16 的缺失会导致核苷酸库依赖于 mTORC1 的增加来克服衰老。
更新日期:2019-11-04
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