Running the Light: Nucleotide Metabolism Drives Bypass of Senescence in Cancer

doi:10.1016/j.tibs.2019.10.007

Trends in Biochemical Sciences

Volume 44, Issue 12, December 2019, Pages 991-993

https://doi.org/10.1016/j.tibs.2019.10.007 Get rights and content

Senescence is engaged in response to oncogenes to suppress proliferation. Cancers rewire metabolism to facilitate proliferation; however, it is not well appreciated how this enables senescence bypass. Recent work by Buj et al. demonstrates that loss of the tumor suppressor p16 engages a mTORC1-dependent increase in nucleotide pools to override senescence.

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Acknowledgments

The authors thank Heather Giza for figure design. C.J.H. was supported by a University of Michigan Center for Gastrointestinal Research Pilot Feasibility Program Award (P30DK034933) and an National Cancer Institute (NCI) National Research Service Award (NRSA) Award (F32CA228328). D.R.W. was supported by the Taubman Institute, the Forbes Institute for Cancer Discovery, a Clinician Scientist Development Award from the American Cancer Society (ACS), and a Career Development award from the NCI