In the present study, we have examined the mixed micellization behavior of promethazine hydrochloride (PMT) and the nonionic surfactant Triton X-100 mixtures at different mole fractions of TX-100 (α1) in aqueous solutions with and without additives (CTAB, glycine, vitamin-C and PVP) using conductometric, tensiometric and fluorescence techniques. PMT belongs to a class of amphiphilic drugs called phenothiazines and is used as an antihistamine, analgesic and sedative. Various parameters which include the ideal critical micelle concentration (cmcid), ideal micellar mole fraction, X1id\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_{1}^{\text{id}}$$\end{document}, of TX-100, micellar composition, X1mic\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_{1}^{\text{mic}}$$\end{document}, of TX-100, interaction parameter (β), activity coefficients (f1mic\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f_{1}^{\text{mic}}$$\end{document} and f2mic\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f_{2}^{\text{mic}}$$\end{document}), thermodynamic parameters ΔGmic0,ΔGad0andΔGmicE\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\left( {\Delta G_{\text{mic}}^{ 0} , \;\Delta G_{\text{ad}}^{0} \;{\text{and}}\;\Delta G_{\text{mic}}^{\text{E}} } \right)$$\end{document} and interfacial parameters (Γmax, Amin, and Πcmc) have been calculated by using Clint’s and Rubingh’s models. In our study, we have found that the cmc < cmcid, β < 0 and f1mic\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f_{1}^{\text{mic}}$$\end{document} and f2mic\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$f_{2}^{\text{mic}}$$\end{document} < 1; all the mixtures show synergism X1id\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_{1}^{\text{id}}$$\end{document} as well as non-ideality. The values of ΔGad0>ΔGmic0\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta G_{\text{ad}}^{0} > \Delta G_{\text{mic}}^{ 0}$$\end{document} for all the systems indicate that adsorption phenomenon occurs primarily as compared to the micellization process. The negative values of ΔGmicE\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta G_{\text{mic}}^{\text{E}}$$\end{document} for all α1 in the absence and presence of additives indicate greater stability of the micelles of mixtures than for the micelles of pure components. The interfacial parameters give information about the packing of amphiphilic molecules.

中文翻译：

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多种技术研究盐酸异丙嗪和Triton X-100在添加剂存在下的混合胶束行为

在本研究中，我们研究了盐酸异丙嗪 (PMT) 和非离子表面活性剂 Triton X-100 混合物在不同摩尔分数 TX-100 (α1) 的水溶液中的混合胶束行为，其中含有和不含添加剂（CTAB、甘氨酸、维生素 C 和 PVP）使用电导、张力和荧光技术。PMT 属于一类称为吩噻嗪的两亲药物，用作抗组胺药、镇痛剂和镇静剂。各种参数，包括理想临界胶束浓度 (cmcid)、理想胶束摩尔分数、X1id\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{ amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$X_{1}^{\text{id}}$$\end{document}, ΔGad0andΔGmicE\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin} {-69pt} \begin{document}$$\left( {\Delta G_{\text{mic}}^{ 0} , \;\Delta G_{\text{ad}}^{0} \;{\ text{and}}\;\Delta G_{\text{mic}}^{\text{E}} } \right)$$\end{document} 和界面参数（Γmax、Amin 和 Πcmc）已经计算通过使用 Clint 和 Rubingh 的模型。在我们的研究中，我们发现 cmc < cmcid, β < 所有混合物都显示协同作用 X1id\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \ setlength{\oddsidemargin}{-69pt} \begin{document}$$X_{1}^{\text{id}}$$\end{document} 以及非理想性。ΔGad0>ΔGmic0\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \ setlength{\oddsidemargin}{-69pt} \begin{document}$$\Delta G_{\text{ad}}^{0} > \Delta G_{\text{mic}}^{ 0}$$\end{所有系统的文档}表明，与胶束化过程相比，吸附现象主要发生。ΔGmicE\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength 的负值{\oddsidemargin}{-69pt} \begin{document}$$\Delta G_{\text{mic}}^{\text{E}}$$\end{document} 对于所有 α1 在不存在和存在添加剂的情况下表明混合物的胶束比纯组分的胶束具有更高的稳定性。界面参数提供有关两亲分子堆积的信息。