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Outcomes of neonates with listeriosis supported with extracorporeal membrane oxygenation from 1991 to 2017.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2019-10-21 , DOI: 10.1038/s41372-019-0534-3
Dianne T Lee 1 , Christine J Park 2 , Steven Peterec 1 , Raffaella Morotti 3 , Robert A Cowles 2
Affiliation  

BACKGROUND Listeriosis may cause severe disease in fetuses and neonates. The outcomes of critically ill neonates with early-onset listeriosis requiring extracorporeal membrane oxygenation (ECMO) from 1975 to 1991 have been reported. OBJECTIVE To update the characteristics and outcomes of neonates with listeriosis supported by ECMO. STUDY DESIGN Retrospective study of neonates with culture-proven listeriosis reported to the Extracorporeal Life Support Organization Registry between 1991 and 2017. Comparisons were made between this cohort and the case series from 1975-1991. RESULTS Twenty-two neonates had culture-proven Listeria monocytogenes infection and required ECMO support. Eight-six percent survived to discharge, compared with 67% in the previous cohort (p = 0.2). The median ECMO duration was 131 h, compared with 209 h in the previous cohort (p = 0.1). Nonsurvivors had a significantly lower pre-ECMO pH (6.91 vs 7.31, p = 0.0006). CONCLUSION The survival of neonates with listeriosis supported with ECMO is high, supporting the use of ECMO as rescue therapy for this condition.

中文翻译:

从1991年至2017年,体外膜氧合作用支持的李斯特菌病新生儿的结局。

背景技术李斯特菌病可引起胎儿和新生儿的严重疾病。据报道,1975年至1991年危重病患的早发性李斯特菌病需要体外膜氧合(ECMO)。目的更新由ECMO支持的新生儿李斯特菌病的特征和预后。研究设计1991年至2017年间向体外生命支持组织注册中心报告的经文化证实的李斯特菌病的新生儿的回顾性研究。对该队列与1975-1991年的病例系列进行了比较。结果22例新生儿具有经培养证实的单核细胞增生性李斯特菌感染,需要ECMO支持。百分之八十六的患者存活到出院,而之前的队列中这一比例为67%(p = 0.2)。ECMO持续时间的中位数为131小时,与前一组的209小时相比(p = 0.1)。非存活者的ECMO前pH值明显较低(6.91对7.31,p = 0.0006)。结论ECMO支持的李斯特菌病新生儿的存活率很高,这支持将ECMO用作这种情况的抢救疗法。
更新日期:2019-10-21
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