Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Outcomes of neonates with listeriosis supported with extracorporeal membrane oxygenation from 1991 to 2017

Journal of Perinatology volume 40, pages 105–111 (2020)Cite this article

Subjects

Abstract

Background

Listeriosis may cause severe disease in fetuses and neonates. The outcomes of critically ill neonates with early-onset listeriosis requiring extracorporeal membrane oxygenation (ECMO) from 1975 to 1991 have been reported.

Objective

To update the characteristics and outcomes of neonates with listeriosis supported by ECMO.

Study design

Retrospective study of neonates with culture-proven listeriosis reported to the Extracorporeal Life Support Organization Registry between 1991 and 2017. Comparisons were made between this cohort and the case series from 1975–1991.

Results

Twenty-two neonates had culture-proven Listeria monocytogenes infection and required ECMO support. Eight-six percent survived to discharge, compared with 67% in the previous cohort (p = 0.2). The median ECMO duration was 131 h, compared with 209 h in the previous cohort (p = 0.1). Nonsurvivors had a significantly lower pre-ECMO pH (6.91 vs 7.31, p = 0.0006).

Conclusion

The survival of neonates with listeriosis supported with ECMO is high, supporting the use of ECMO as rescue therapy for this condition.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1

Similar content being viewed by others

References

  1. Centers for Disease Control and Prevention. Listeria (listeriosis) surveillance. Centers for Disease Control and Prevention; 2016. Web. https://www.cdc.gov/listeria/surveillance.html.

  2. Lamont RF, Sobel J, Mazaki-Tovi S, Kusanovic JP, Vaisbuch E, Kim SK, et al. Listeriosis in human pregnancy: a systematic review. J Perinat Med. 2011;39:227–36.

    Article  Google Scholar 

  3. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2007. Centers for Disease Control and Prevention; 2011. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2007-508c.pdf.

  4. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2008. Centers for Disease Control and Prevention; 2011. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2008-508c.pdf.

  5. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2009. Centers for Disease Control and Prevention; 2011. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2009-508c.pdf.

  6. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2010. Centers for Disease Control and Prevention; 2012. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2010-508c.pdf.

  7. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2011. Centers for Disease Control and Prevention; 2013. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2011-508c.pdf.

  8. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2012. Centers for Disease Control and Prevention; 2014. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2012-508c.pdf.

  9. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2013. Centers for Disease Control and Prevention; 2015. Web. https://www.cdc.gov/listeria/pdf/listeria-annual-summary-2013-508c.pdf.

  10. Centers for Disease Control and Prevention. National enteric disease surveillance: Listeria annual summary, 2014. Centers for Disease Control and Prevention; 2015. Web. https://www.cdc.gov/nationalsurveillance/pdfs/listeria-annual-summary-2014-508.pdf.

  11. Sapuan S, Kortsalioudaki C, Anthony M, Chang J, Embleton ND, Geethanath RM, et al. Neonatal listeriosis in the UK 2004-2014. J Infect. 2017;74:236–42.

    Article  Google Scholar 

  12. Boucher M, Yonekura ML. Perinatal listeriosis (early-onset): correlation of antenatal manifestations and neonatal outcome. Obstet Gynecol. 1986;68:593–7.

    CAS  PubMed  Google Scholar 

  13. Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing EJ. Listeriosis during pregnancy: a case series and review of 222 cases. Medicine. 2002;81:260–9.

    Article  Google Scholar 

  14. Farber JM, Peterkin PI. Listeria monocytogenes, a food-borne pathogen. Microbiol Rev. 1991;55:476–511.

    CAS  PubMed  PubMed Central  Google Scholar 

  15. McLauchlin J. Human listeriosis in Britain, 1967-85, a summary of 722 cases. 1. Listeriosis during pregnancy and in the newborn. Epidemiol Infect. 1990;104:181–9.

    Article  CAS  Google Scholar 

  16. McLaughlin J, Luca MG, Jones MN, D’amato M, Dockray GJ, Thompson DG. Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology. 1999;116:46–53.

    Article  CAS  Google Scholar 

  17. Spencer JA. Perinatal listeriosis. Br Med J. 1987;295:349.

    Article  CAS  Google Scholar 

  18. Hirschl RB, Butler M, Coburn CE, Bartlett RH, Baumgart S. Listeria monocytogenes and severe newborn respiratory failure supported with extracorporeal membrane oxygenation. Arch Pediatr Adolesc Med. 1994;148:513–7.

    Article  CAS  Google Scholar 

  19. Barbaro RP, Paden ML, Guner YS, Raman L, Ryerson LM, Alexander P, et al. Pediatric Extracorporeal Life Support Organization Registry International Report 2016. ASAIO J. 2017;63:456–63.

    Article  Google Scholar 

  20. Extracorporeal Life Support Organization (ELSO). International Summary of ELSO Registry Report. Ann Arbor, MI: Extracorporeal Life Support Organization; 2017.

  21. Vugia D, Cronquist A, Hadler J, Tobin-D'Angelo M, Blythe D, Smith K, et al. Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food–10 states, 2007. MMWR Morb Mortal Wkly Rep. 2008;57:366–70.

  22. Wadhwa Desai R, Smith MA. Pregnancy-related listeriosis. Birth Defects Res. 2017;109:324–35.

    Article  CAS  Google Scholar 

  23. Linnan MJ, Mascola L, Lou XD, Goulet V, May S, Salminen C, et al. Epidemic listeriosis associated with Mexican-style cheese. N Engl J Med. 1988;319:823–8.

    Article  CAS  Google Scholar 

  24. Bhatt P, Lekshminarayanan A, Donda K, Dapaah-Siakwan F, Patel A, Parat S, et al. National trends in neonatal extracorporeal membrane oxygenation in the United States. J Perinatol. 2018;38:1106–13.

    Article  Google Scholar 

  25. Mahmood B, Newton D, Pallotto EK. Current trends in neonatal ECMO. Semin Perinatol. 2018;42:80–8.

    Article  Google Scholar 

  26. Sahni R. Continuous noninvasive monitoring in the neonatal ICU. Curr Opin Pediatr. 2017;29:141–8.

    Article  Google Scholar 

  27. Blot S, Afonso E, Labeau S. Recent advances in multidisciplinary critical care. Am J Crit Care. 2015;24:75–86.

    Article  Google Scholar 

  28. Betit P. Technical advances in the field of ECMO. Respir Care. 2018;63:1162–73.

    Article  Google Scholar 

  29. Zangrillo A, Landoni G, Biondi-Zoccai G, Greco M, Greco T, Frati G, et al. A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc. 2013;15:172–8.

    PubMed  Google Scholar 

  30. Murphy DA, Hockings LE, Andrews RK, Aubron C, Gardiner EE, Pellegrino VA, et al. Extracorporeal membrane oxygenation-hemostatic complications. Transfus Med Rev. 2015;29:90–101.

    Article  Google Scholar 

  31. Bamat NA, Tharakan SJ, Connelly JT, Hedrick HL, Lorch SA, Rintoul NE, et al. Venoarterial extracorporeal life support for neonatal respiratory failure: indications and impact on mortality. ASAIO J. 2017;63:490–5.

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank Veronika Shabanova, Ph.D., statistician from the Yale School of Public Health, for help with the statistical analyses. We also thank the ELSO Organization for permission to query their database.

Author information

Authors and Affiliations

  1. Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Yale School of Medicine, New Haven, CT, USA

    Dianne T. Lee & Steven Peterec

  2. Department of Surgery, Division of Pediatric Surgery, Yale School of Medicine, New Haven, CT, USA

    Christine J. Park & Robert A. Cowles

  3. Department of Pathology, Yale School of Medicine, New Haven, CT, USA

    Raffaella Morotti

Authors
  1. Dianne T. Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christine J. Park
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Steven Peterec
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Raffaella Morotti
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert A. Cowles
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Robert A. Cowles.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lee, D.T., Park, C.J., Peterec, S. et al. Outcomes of neonates with listeriosis supported with extracorporeal membrane oxygenation from 1991 to 2017. J Perinatol 40, 105–111 (2020). https://doi.org/10.1038/s41372-019-0534-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41372-019-0534-3

This article is cited by

Search

Advanced search

Quick links