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Facile access to chiral non-natural amino acids
Nature Catalysis ( IF 42.8 ) Pub Date : 2019-10-11 , DOI: 10.1038/s41929-019-0367-7
Oriol Planas , Josep Cornella

Given the importance of enantioenriched β2- and β3-amino acids as building blocks, direct and versatile methods for their synthesis are highly coveted by organic chemists. Now, using easily accessible 1,3-oxazinane motifs, a regiodivergent and enantioselective C–H functionalization method permits their synthesis in a straightforward and practical fashion.

中文翻译:

容易获得手性非天然氨基酸

鉴于对映体富集的β2-和β3-氨基酸作为基本组成部分的重要性,有机化学家们高度渴望直接和通用的合成方法。现在,使用容易获得的1,3-恶嗪烷基序,区域发散和对映选择性的CH功能化方法可以直接且实用的方式合成它们。
更新日期:2019-10-12
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