Given the importance of enantioenriched β2- and β3-amino acids as building blocks, direct and versatile methods for their synthesis are highly coveted by organic chemists. Now, using easily accessible 1,3-oxazinane motifs, a regiodivergent and enantioselective C–H functionalization method permits their synthesis in a straightforward and practical fashion.
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References
Kudo, F., Miyanaga, A. & Eguchi, T. Nat. Prod. Rep. 31, 1056–1073 (2014).
Steer, D. L., Lew, R. A., Perlmutter, P., Smith, A. I. & Aguilar, M.-I. Curr. Med. Chem. 9, 811–822 (2002).
Weiner, B., Szymański, W., Janssen, D. B., Minnaard, A. J. & Feringa, B. L. Chem. Soc. Rev. 39, 1656–1691 (2010).
Lin, W., Zhang, K.-F., Baudoin, O. Nat. Catal. https://doi.org/10.1038/s41929-019-0336-1 (2019).
Millet, A., Larini, P., Clot, E. & Baudoin, O. Chem. Sci. 4, 2241–2247 (2013).
McGrath, M. J. & O’Brien, P. J. Am. Chem. Soc. 127, 16378–16379 (2005).
Lait, S. M., Rankic, D. A. & Keay, B. A. Chem. Rev. 107, 767–796 (2007).
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Planas, O., Cornella, J. Facile access to chiral non-natural amino acids. Nat Catal 2, 839–840 (2019). https://doi.org/10.1038/s41929-019-0367-7
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DOI: https://doi.org/10.1038/s41929-019-0367-7
