当前位置：
X-MOL 学术
›
J. Antibiot.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
New natural products to meet the antibiotic crisis: a personal journey.
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-08-28 , DOI: 10.1038/s41429-019-0224-6 Masayuki Igarashi 1
The Journal of Antibiotics ( IF 2.1 ) Pub Date : 2019-08-28 , DOI: 10.1038/s41429-019-0224-6 Masayuki Igarashi 1
Affiliation
|
The use of natural products and their derivatives has evolved as a promising approach for the treatment of various infectious diseases, particularly to combat drug-resistant microbial strains. In addition, these natural products characterized by the presence of novel structures and mechanisms of action may provide guidance toward the development of potential new chemotherapies. In the present review, antimicrobial resistance (AMR) is briefly introduced and research focused on the identification and characterization of actinomycete metabolites for antimicrobial activity is discussed. Three compounds, i.e., walkmycin B, waldiomycin, and signamycin B, with novel mechanisms of action as histidine kinase inhibitors, were isolated from the metabolites of actinomycetes. New antituberculosis antibiotics, tuberlactomicin A and caprazamycins, were discovered, and amycolamicin was identified as an antimethicillin-resistant Staphylococus aureus antibiotic. The discovery of these compounds encourages the discovery and investigation of more natural products active against antimicrobial-resistant species, thus providing scaffold for the development of effective drugs against various AMR species.
中文翻译：
应对抗生素危机的新天然产品：个人旅程。
天然产物及其衍生物的使用已发展成为治疗各种传染病的有前途的方法，特别是对抗耐药微生物菌株。此外，这些以存在新结构和作用机制为特征的天然产物可能为开发潜在的新化学疗法提供指导。在本综述中，简要介绍了抗菌素耐药性 (AMR)，并讨论了针对放线菌代谢物的抗菌活性鉴定和表征的研究。从放线菌的代谢物中分离出三种化合物，即沃地霉素B、瓦地霉素和signamycin B，它们具有作为组氨酸激酶抑制剂的新作用机制。新型抗结核抗生素，结核菌素 A 和卡普拉霉素，被发现，并确定了amycolamicin是一种抗甲氧西林金黄色葡萄球菌抗生素。这些化合物的发现鼓励发现和研究更多对抗菌素耐药物种具有活性的天然产物，从而为开发针对各种 AMR 物种的有效药物提供支架。
更新日期：2020-01-17
中文翻译：
应对抗生素危机的新天然产品：个人旅程。
天然产物及其衍生物的使用已发展成为治疗各种传染病的有前途的方法，特别是对抗耐药微生物菌株。此外，这些以存在新结构和作用机制为特征的天然产物可能为开发潜在的新化学疗法提供指导。在本综述中，简要介绍了抗菌素耐药性 (AMR)，并讨论了针对放线菌代谢物的抗菌活性鉴定和表征的研究。从放线菌的代谢物中分离出三种化合物，即沃地霉素B、瓦地霉素和signamycin B，它们具有作为组氨酸激酶抑制剂的新作用机制。新型抗结核抗生素，结核菌素 A 和卡普拉霉素，被发现，并确定了amycolamicin是一种抗甲氧西林金黄色葡萄球菌抗生素。这些化合物的发现鼓励发现和研究更多对抗菌素耐药物种具有活性的天然产物，从而为开发针对各种 AMR 物种的有效药物提供支架。
京公网安备 11010802027423号