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The role of intraoperative parathyroid hormone (IOPTH) determination for identification and surgical strategy of sporadic multiglandular disease in primary hyperparathyroidism (pHPT).
Best Practice & Research Clinical Endocrinology & Metabolism ( IF 6.1 ) Pub Date : 2019-08-08 , DOI: 10.1016/j.beem.2019.101310
Jagdeep Singh Bhangu 1 , Philipp Riss 1
Affiliation  

Intraoperative PTH monitoring (IOPTH) made minimally invasive parathyroidectomy in patients with primary HPT possible. However, with the increasing accuracy of preoperative localization studies there is a growing discussion if IOPTH is necessary in patients with localized single gland disease (concordant preoperative localization studies). Different interpretation criteria have been developed - each with their particular advantages and disadvantages, but the "perfect" criterion is still missing. Despite several pitfalls, which can be recognized intraoperatively and do not necessarily lead to a more extensive surgery, IOPTH seems to be a useful adjunct in surgery for PHPT. However, according to current guidelines, selected patients may be operated without IOPTH but need to be informed about the possibly increased risk of recurrent disease.

中文翻译:

术中甲状旁腺激素(IOPTH)测定在原发性甲状旁腺功能亢进症(pHPT)中散发性多腺疾病的鉴定和手术策略中的作用。

术中PTH监测(IOPTH)使原发性HPT患者进行微创甲状旁腺切除术成为可能。然而,随着术前定位研究准确性的提高,对于局限性单腺疾病患者是否需要IOPTH的讨论越来越多(一致的术前定位研究)。已经开发了不同的解释标准-每个解释标准都有其各自的优点和缺点,但是仍然缺少“完美”的标准。尽管存在一些陷阱,这些陷阱可以在术中识别出来,并不一定导致更广泛的手术,但IOPTH似乎是PHPT手术的有用辅助手段。但是,根据当前的指南,选定的患者可能无需进行IOPTH手术,但需要告知其复发疾病的风险可能增加。
更新日期:2019-08-08
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