The efficacy of metformin in treating cancer has been extensively investigated since epidemiologic studies associated this anti-diabetic drug with a lower risk of cancer incidence. Since tumors are complex systems, in which cancer cells coexist and interact with several different types of non-malignant cells, it is not surprising that anti-cancer drugs affect not only cancer cells, but also the abundance and functions of cells of the tumor microenvironment. Recent years have seen a wide collection of reports showing how metformin, as well as other complex I inhibitors, may influence cancer progression by modulating the phenotype of non-transformed cells in a tumor. In this review, we particularly focus on the effect of metformin on angiogenesis, cancer-associated fibroblasts, tumor-associated macrophages and cancer immunosuppression.

中文翻译：

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二甲双胍对肿瘤微环境的多方面影响。

二甲双胍治疗癌症的功效已得到广泛研究，因为流行病学研究表明这种抗糖尿病药物与癌症发生的风险较低有关。由于肿瘤是复杂的系统，其中癌细胞共存并与几种不同类型的非恶性细胞相互作用，因此抗癌药物不仅影响癌细胞，而且影响肿瘤微环境细胞的丰度和功能也就不足为奇了。 。近年来，已有大量报道表明二甲双胍以及其他复合物I抑制剂如何通过调节肿瘤中未转化细胞的表型来影响癌症进展。在这篇综述中，我们特别关注二甲双胍对血管生成，与癌症相关的成纤维细胞，与肿瘤相关的巨噬细胞和癌症免疫抑制的作用。