ReviewThe multifaceted effects of metformin on tumor microenvironment
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Abbreviations
AMPK
AMP activated kinase
Arg1
arginase
BMDM
bone marrow-derived macrophagesn
CAFs
cancer associated fibroblasts
CI
complex I
HIF-1α
hypoxia-inducible factor 1 alpha
LPS
lipopolysaccharide
mTORC1
mammalian target of rapamycin complex I
MDSC
myeloid-derived suppressor cell
NK
natural killer cell
PD-1
Programmed cell death protein 1
PD-L1
programmed death ligand 1
PMA
phorbol myristate acetate
TAM
tumor associated macrophage
TIL
tumor infiltrating lymphocyte
TME
tumor microenvironment
Treg
regulatory T-cells
Keywords
Cancer metabolism
Metformin
Respiratory complex I
Tumor microenvironment
Angiogenesis
Cancer-associated fibroblasts
Tumor-associated macrophages
Cancer immunosuppression
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© 2019 The Authors. Published by Elsevier Ltd.