The aim of the present study was to evaluate the histological, histochemical, and stereological changes caused by mycophenolate mofetil (MMF) on the tunica albuginea of rat penises submitted to an injection of transforming growth factor beta (TGF-β) for the induction of Peyronie’s disease (PD). Twenty adult male Wistar rats were divided into four groups: Control group; TGF-β group (TGF-β injection); MMF-7d group (treated with MMF 7 days after induction with TGF-β); and MMF-30d group (treated with MMF 30 days after induction with TGF-β). The steorological evaluation included the relative volume of different types of connective fibres of the tunica albuginea. The histochemical analysis revealed the fragmentation and degradation of elastin in the tunica albuginea. This process was partially reversed in the MMF-7d group and a situation very close to normality was observed in the MMF-30d group. In the collagen III/collagen I ratio it was observed increase in this ratio in the TGF-β (59.4 ± 5.53) and MMF-7d (49 ± 18.2) groups and a decrease in the MMF-30d group (28.7 ± 4), approaching normality. The injection of TGF-β promoted fibrotic alterations in the penile tunica albuginea in Wistar rats corresponding to PD. In this model, MMF acts as a regenerating anti-fibrotic agent.

本研究的目的是评估霉菌酚酸酯（MMF）对大鼠阴茎白膜引起的组织学，组织化学和体视学变化的影响，该阴茎需注射转化生长因子β（TGF-β）诱导百日咳。疾病（PD）。将二十只成年雄性Wistar大鼠分成四组：对照组；和对照组。转化生长因子-β组（TGF-β注射液）；MMF-7d组（用TGF-β诱导后7天用MMF治疗）；和MMF-30d组（用TGF-β诱导后30天用MMF治疗）。血液学评估包括白膜不同类型结缔纤维的相对体积。组织化学分析显示白膜中弹性蛋白的分裂和降解。在MMF-7d组中该过程被部分逆转，并且在MMF-30d组中观察到非常接近正常的情况。在胶原III /胶原I的比例中，观察到TGF-β（59.4±5.53）和MMF-7d（49±18.2）组的比例增加，而MMF-30d组（28.7±4）的比例降低，接近常态。注射TGF-β可促进Wistar大鼠相应于PD的阴茎白膜纤维化改变。