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Signal-induced PARP1-Erk synergism mediates IEG expression
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2019-04-12 , DOI: 10.1038/s41392-019-0042-0
Malka Cohen-Armon 1, 2 , Adva Yeheskel 3 , John M Pascal 4
Affiliation  

A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy.



中文翻译:


信号诱导的 PARP1-Erk 协同介导 IEG 表达



最近公开的 Erk 诱导的 PARP1 激活介导立即早期基因 (IEG) 的表达,以响应与记忆获取、发育和增殖有关的各种细胞外和细胞内信号。在这里,我们回顾了这种机制,该机制是由刺激诱导的 PARP1 与转位到细胞核的磷酸化 Erk 结合而启动的。它们的结合以协同作用维持其持久活性,这为靶向治疗提供了新模式。

更新日期:2019-11-18
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