当前位置：
X-MOL 学术
›
Signal Transduct. Target Ther.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Signal-induced PARP1-Erk synergism mediates IEG expression
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2019-04-12 , DOI: 10.1038/s41392-019-0042-0 Malka Cohen-Armon 1, 2 , Adva Yeheskel 3 , John M Pascal 4
中文翻译：
信号诱导的 PARP1-Erk 协同介导 IEG 表达
更新日期：2019-11-18
Signal Transduction and Targeted Therapy ( IF 40.8 ) Pub Date : 2019-04-12 , DOI: 10.1038/s41392-019-0042-0 Malka Cohen-Armon 1, 2 , Adva Yeheskel 3 , John M Pascal 4
Affiliation
|
A recently disclosed Erk-induced PARP1 activation mediates the expression of immediate early genes (IEG) in response to a variety of extra- and intra-cellular signals implicated in memory acquisition, development and proliferation. Here, we review this mechanism, which is initiated by stimulation-induced binding of PARP1 to phosphorylated Erk translocated into the nucleus. Their binding maintains their long-lasting activity in a synergism, which offers a new pattern for targeted therapy.
中文翻译：
信号诱导的 PARP1-Erk 协同介导 IEG 表达
最近公开的 Erk 诱导的 PARP1 激活介导立即早期基因 (IEG) 的表达，以响应与记忆获取、发育和增殖有关的各种细胞外和细胞内信号。在这里，我们回顾了这种机制，该机制是由刺激诱导的 PARP1 与转位到细胞核的磷酸化 Erk 结合而启动的。它们的结合以协同作用维持其持久活性，这为靶向治疗提供了新模式。
京公网安备 11010802027423号