Purpose

This work aimed to explore the relationship between epidermal growth factor (EGF) and β-human chorionic gonadotropin (β-HCG) and ectopic pregnancy types and impact on prognosis.

Methods

Twenty women with normal pregnancies (NPs) were recruited as control group, and twenty women each with tubal pregnancy (TP) and cervical pregnancy (CP) were recruited. Blood samples were collected to detect EGF and β-HCG. Data on length of hospital stay and incidence of complications were collected. The differences in serum EGF and β-HCG levels were compared among groups and within various types of ectopic pregnancy using analysis of variance and Pearson correlation analysis.

Results

Serum EGF and β-HCG were notably lower in TP and CP group vs. controls (P < 0.05). In subgroup analysis within the types of ectopic pregnancy, serum EGF levels were drastically higher in TP group vs. CP group (P < 0.05). Serum EGF levels were negatively correlated with pregnancy outcomes and incidence of complications (P < 0.05). In patients with TP and CP, serum EGF and β-HCG recovery time and hospital stay differed drastically (P < 0.05). Serum EGF and β-HCG levels showed optimal cutoff values identified at 2.65 μg/L and 11,745.35 IU/L, respectively. The corresponding area under the curve (AUC) values were 0.885 and 0.841.

Conclusion

Elevated levels of EGF may be associated with the occurrence of ectopic pregnancy and may impact the type of ectopic pregnancy, pregnancy outcomes, and the incidence of complications. Further clinical research is warranted to investigate these findings.

中文翻译：

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血清表皮生长因子、β-人绒毛膜促性腺激素水平与宫外孕类型及预后的关系

目的

本工作旨在探讨表皮生长因子（EGF）和β-人绒毛膜促性腺激素（β-HCG）与宫外孕类型的关系及对预后的影响。

方法

招募 20 名正常妊娠（NPs）女性作为对照组，另招募 20 名输卵管妊娠（TP）和宫颈妊娠（CP）女性。采集血样检测EGF和β-HCG。收集有关住院时间和并发症发生率的数据。采用方差分析和Pearson相关分析比较各组间及不同类型宫外孕内血清EGF和β-HCG水平的差异。

结果

TP组和CP组血清EGF和β-HCG显着低于对照组（P  < 0.05）。异位妊娠类型亚组分析中，TP组血清EGF水平显着高于CP组（P  < 0.05）。血清EGF水平与妊娠结局及并发症发生率呈负相关（P  < 0.05）。 TP和CP患者血清EGF和β-HCG恢复时间和住院时间差异显着（P  < 0.05）。血清 EGF 和 β-HCG 水平显示最佳截止值分别为 2.65 μg/L 和 11,745.35 IU/L。相应的曲线下面积（AUC）值为0.885和0.841。

结论

EGF水平升高可能与宫外孕的发生有关，并可能影响宫外孕的类型、妊娠结局和并发症的发生率。需要进一步的临床研究来调查这些发现。