Regioselective C–H functionalization of aromatics remains a challenging problem in organic synthesis, particularly for meta-selective C–H borylations of phenols derivatives. Here, pivalic acid promoted iridium-catalyzed meta-selective C–H borylation of phenols is disclosed. Various substituted phenol directives including bioactive compounds are found to be tolerated, affording the corresponding borylated products in moderate to good yields under concise reaction conditions.

中文翻译：

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铱催化苯酚衍生物的间位选择性C-H硼化反应

芳烃的区域选择性 C-H 官能化仍然是有机合成中的一个具有挑战性的问题，特别是对于酚类衍生物的间位选择性 C-H 硼基化。在此，公开了新戊酸促进的铱催化的苯酚间位选择性C-H硼化反应。发现包括生物活性化合物在内的各种取代苯酚指令是可以耐受的，在简洁的反应条件下以中等至良好的产率提供相应的硼化产物。