Iridium-catalyzed meta-selective C–H borylation of phenol derivatives

Wenjie Ju; Du Gao; Min Liang; Shuxiong Han; Chuangchuang Liu; Yingsheng Zhao

doi:10.1039/D4QO00516C

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Iridium-catalyzed meta-selective C–H borylation of phenol derivatives†

Wenjie Ju,‡^a Du Gao,‡^a Min Liang,^a Shuxiong Han,^a Chuangchuang Liu^a and Yingsheng Zhao

*^ab

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* Corresponding authors

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R. China
E-mail: yszhao@suda.edu.cn

^b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453000, P.R. China

Abstract

Regioselective C–H functionalization of aromatics remains a challenging problem in organic synthesis, particularly for meta-selective C–H borylations of phenols derivatives. Here, pivalic acid promoted iridium-catalyzed meta-selective C–H borylation of phenols is disclosed. Various substituted phenol directives including bioactive compounds are found to be tolerated, affording the corresponding borylated products in moderate to good yields under concise reaction conditions.

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DOI: https://doi.org/10.1039/D4QO00516C
Article type: Research Article
Submitted: 20 Mar 2024
Accepted: 25 Apr 2024
First published: 27 Apr 2024

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Org. Chem. Front., 2024, Advance Article

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Iridium-catalyzed meta-selective C–H borylation of phenol derivatives

W. Ju, D. Gao, M. Liang, S. Han, C. Liu and Y. Zhao, Org. Chem. Front., 2024, Advance Article , DOI: 10.1039/D4QO00516C

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Iridium-catalyzed meta-selective C–H borylation of phenol derivatives†

Abstract

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Iridium-catalyzed meta-selective C–H borylation of phenol derivatives

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