A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem of Rhamnus crenata, together with eight known compounds 2–9. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC₅₀ values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds 3, 5, and 6 also showed potent DPPH radical scavenging activities with IC₅₀ values of 95.47 ± 6.18, 68.27 ± 5.38, and 66.25 ± 4.20 μM, respectively.

一种新的萘衍生物，7-乙酰基-8-羟基-3-甲氧基-6-甲基萘-1-乙酸酯 ( 1 )，已从Rhamnus crenata的茎中分离出来，以及八种已知化合物2-9。通过光谱和质谱分析确定了新化合物1的结构。在分离株中，大黄素 ( 3 )、大黄素甲醚 ( 4 )、槲皮素 3-O- α -L-吡喃鼠李糖苷 ( 5 ) 和槲皮素 7-O- α -L-吡喃鼠李糖苷 ( 6 ) 显示出有效的抑制作用，IC ₅₀值为针对 LPS 诱导的 NO 生成，分别为 33.18 ± 2.73、35.52 ± 3.27、28.05 ± 1.85 和 26.41 ± 3.01 μM。此外，化合物3、5和6还表现出有效的DPPH自由基清除活性，IC 50_值分别为95.47±6.18、68.27±5.38和66.25±4.20μM。