A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem of Rhamnus crenata, together with eight known compounds 2–9. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds 3, 5, and 6 also showed potent DPPH radical scavenging activities with IC50 values of 95.47 ± 6.18, 68.27 ± 5.38, and 66.25 ± 4.20 μM, respectively.
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Acknowledgment
This research was supported by a grant from the Ministry of Science and Technology, Taiwan (MOST 109-2320-B-010-029-MY3), awarded to Prof. J.-J. Chen. This work was also supported by grants from Cathay General Hospital (CGH-MR-A11124) and Kaohsiung Veterans General Hospital Tainan Branch (VHYK 112-01 and VHYK 111-02).
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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2024, pp. 44–47.
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Chin, CH., Liaw, CC., Chang, TH. et al. Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata. Chem Nat Compd 60, 50–54 (2024). https://doi.org/10.1007/s10600-024-04251-4
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DOI: https://doi.org/10.1007/s10600-024-04251-4