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Hepatoprotective Phenylpropanoid Glycosides from Highland Barley Monascus purpureus
Chemistry of Natural Compounds ( IF 0.8 ) Pub Date : 2024-01-30 , DOI: 10.1007/s10600-024-04250-5
Rongrui Wei , Qinyuan Wang , Qingyuan Lin , Xianbao Jiang , Zhongli Zhang , Lan Cao , Jiazeng Guo , Qinge Ma

A new phenylpropanoid glycoside, named 4-O-β-D-glucopyranosyl-7-phenyl-9-propenyl ketone-9-O-β-Dglucopyranosyl-(6′′→1′′′)-6′′-O-α-L-rhamnopyranose (1), and four known phenylpropanoid glycosides 2–5 were isolated from highland barley Monascus purpureus Went for the first time. Their structures were determined by their comprehensive spectral data and reported references. Compounds 1–5 were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 cells with bicyclol as positive control. As a result, compounds 1 and 2 exhibited moderate hepatoprotective activities.



中文翻译:

青稞红曲霉中的保肝苯丙苷

一种新的苯丙酸苷,命名为4-O- β -D-吡喃葡萄糖基-7-苯基-9-丙烯基酮-9-O- β -D吡喃葡萄糖基-(6′′→1′′′)-6′′-O- α-L-吡喃鼠李糖( 1 )和4种已知的苯丙苷2-5均为首次从青稞红曲霉中分离得到。它们的结构是通过其综合光谱数据和报告的参考文献确定的。以双环醇作为阳性对照,评估了化合物1-5对 WB-F344 细胞中 D-半乳糖胺诱导的毒性的保肝活性。结果,化合物12表现出中等的保肝活性。

更新日期:2024-01-31
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