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Hepatoprotective Phenylpropanoid Glycosides from Highland Barley Monascus purpureus

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Chemistry of Natural Compounds Aims and scope

A new phenylpropanoid glycoside, named 4-O-β-D-glucopyranosyl-7-phenyl-9-propenyl ketone-9-O-β-Dglucopyranosyl-(6′′→1′′′)-6′′-O-α-L-rhamnopyranose (1), and four known phenylpropanoid glycosides 2–5 were isolated from highland barley Monascus purpureus Went for the first time. Their structures were determined by their comprehensive spectral data and reported references. Compounds 1–5 were evaluated for their hepatoprotective activities against D-galactosamine-induced toxicity in WB-F344 cells with bicyclol as positive control. As a result, compounds 1 and 2 exhibited moderate hepatoprotective activities.

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Acknowledgment

This study was supported by National Natural Science Foundation of China (82360825), Jiangxi Provincial Natural Science Foundation (20224BAB206112), Science and Technology Project of Jiangxi Health Commission (202211413), and Doctoral Research Initiation Fund Project of Jiangxi University of Traditional Chinese Medicine (2018BSZR007, 2018BSZR010).

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Authors and Affiliations

  1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Personnel Division, College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, P. R. China

    Rongrui Wei, Qinyuan Wang, Qingyuan Lin, Xianbao Jiang, Zhongli Zhang, Lan Cao & Qinge Ma

  2. College of Jewelry and Jade Carving, Nanyang Normal University, 473061, Nanyang, P. R. China

    Jiazeng Guo

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  1. Rongrui Wei
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  2. Qinyuan Wang
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  3. Qingyuan Lin
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  4. Xianbao Jiang
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  5. Zhongli Zhang
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  6. Lan Cao
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  7. Jiazeng Guo
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  8. Qinge Ma
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Corresponding authors

Correspondence to Zhongli Zhang, Lan Cao, Jiazeng Guo or Qinge Ma.

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Published in Khimiya Prirodnykh Soedinenii, No. 1, January–February, 2024, pp. 40–43

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Wei, R., Wang, Q., Lin, Q. et al. Hepatoprotective Phenylpropanoid Glycosides from Highland Barley Monascus purpureus. Chem Nat Compd 60, 45–49 (2024). https://doi.org/10.1007/s10600-024-04250-5

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  • DOI: https://doi.org/10.1007/s10600-024-04250-5

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