Abstract

The peculiarities of the influence of cytokines and metabolites of the systemic inflammatory reaction and stress-implementing and nutritional factors contributing to the transformation of the phenotype of the resident intestinal microflora with an increase in its virulence are described. From the perspective of expression of genes and conformations of proteins and phospholipids, the influence of temperature as a signaling factor in increasing the virulence of the intestinal microbiome is considered. Evolutionarily formed mechanisms of expression of the maximum pathogenic phenotype of microorganisms and, thus, achieving an increase in their biomass and maximum dissemination through the microorganism compartments increase the probability of the transmission of commensals to another biotope, i.e., increases the probability of their survival after the death of the host organism. To prevent bacterial translocation after the relief of critical conditions, early enteral administration of β-glucans in food mixtures, iron excretion, and relief of inorganic phosphate deficiency, including by induction of alkaline phosphatase synthesis, are substantiated.

中文翻译：

---

共生体毒力动态：预防性表型突变

摘要

描述了全身炎症反应的细胞因子和代谢物的影响以及应激实施和营养因素的影响的特殊性，这些因素有助于肠道常驻微生物群表型的转变及其毒力的增加。从基因表达以及蛋白质和磷脂构象的角度，考虑温度作为信号因素对增加肠道微生物组毒力的影响。进化形成的微生物最大致病表型表达机制，从而实现微生物生物量的增加和通过微生物区室的最大传播，增加了共生体传播到另一个生境的可能性，即增加了它们在微生物繁殖后存活的可能性。宿主生物体的死亡。为了防止危急情况缓解后细菌移位，早期肠内施用食物混合物中的β-葡聚糖、铁排泄和缓解无机磷酸盐缺乏（包括通过诱导碱性磷酸酶合成）已得到证实。