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DNA damage twists base choreography
Nature Chemical Biology ( IF 12.9 ) Pub Date : 2023-04-24 , DOI: 10.1038/s41589-023-01315-4
Serge L Smirnov 1
Affiliation  

The mechanisms responsible for replicative misincorporation of an adenine into DNA opposite 8-oxoguanine (8OG) remain obscure. A new study suggests that 8OG redistributes the balance between several mispair conformations, enabling the high rates of misincorporation of adenine paired with 8OG by DNA polymerases.

中文翻译:

DNA 损伤扭曲了碱基编排

腺嘌呤复制错误掺入与 8-氧代鸟嘌呤 (8OG) 相反的 DNA 的机制仍不清楚。一项新的研究表明,8OG 重新分配了几种错配构象之间的平衡,从而使 DNA 聚合酶能够高比例地错误掺入与 8OG 配对的腺嘌呤。
更新日期:2023-04-25
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