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DNA damage

DNA damage twists base choreography

Nature Chemical Biology volume 19, pages 797–798 (2023)Cite this article

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The mechanisms responsible for replicative misincorporation of an adenine into DNA opposite 8-oxoguanine (8OG) remain obscure. A new study suggests that 8OG redistributes the balance between several mispair conformations, enabling the high rates of misincorporation of adenine paired with 8OG by DNA polymerases.

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Fig. 1: The dominant mutagenic (Aanti–8OGsyn) ground state in dynamic exchange with pre-existing minor states (Asyn–8OGanti) and (Aanti–8OGanti).

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  1. Department of Chemistry, Western Washington University, Bellingham, WA, USA

    Serge L. Smirnov

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  1. Serge L. Smirnov
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Correspondence to Serge L. Smirnov.

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Smirnov, S.L. DNA damage twists base choreography. Nat Chem Biol 19, 797–798 (2023). https://doi.org/10.1038/s41589-023-01315-4

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