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New genetic loci associated with gestational duration show a complex link with birth weight
Nature Genetics ( IF 31.7 ) Pub Date : 2023-04-04 , DOI: 10.1038/s41588-023-01344-8


A GWAS meta-analysis, combined with tracing the parental transmitted and non-transmitted alleles in parent–offspring pairs, enabled us to distinguish the effects of maternal and fetal genomes on gestational duration and their links with birth weight. The identified genes are more likely to be differentially expressed during labor and show signs of antagonistic pleiotropy with fetal genome effects on birth weight.

中文翻译:

与妊娠持续时间相关的新基因位点显示出与出生体重的复杂联系

GWAS 荟萃分析结合追踪父母-后代中父母遗传和非遗传等位基因,使我们能够区分母体和胎儿基因组对妊娠持续时间的影响及其与出生体重的联系。鉴定出的基因更有可能在分娩期间差异表达,并显示出与胎儿基因组对出生体重影响的拮抗多效性迹象。
更新日期:2023-04-05
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