A GWAS meta-analysis, combined with tracing the parental transmitted and non-transmitted alleles in parent–offspring pairs, enabled us to distinguish the effects of maternal and fetal genomes on gestational duration and their links with birth weight. The identified genes are more likely to be differentially expressed during labor and show signs of antagonistic pleiotropy with fetal genome effects on birth weight.
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References
Chawanpaiboon, S. et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob. Health 7, e37–e46 (2019). Estimates of preterm delivery at the global, regional and national level.
Perin, J. et al. Global, regional, and national causes of under-5 mortality in 2000-19: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet Child Adolesc. Health 6, 106–115 (2022). Major causes of global deaths in neonates and children under five years of age.
Zhang, G. et al. Genetic associations with gestational duration and spontaneous preterm birth. NEJM. 377, 1156–1167 (2017). The discovery of the first robust genetic associations with gestational duration.
Warrington, N. M. et al. Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors. Nat. Genet. 51, 804–814 (2019). This work presents a statistical framework for teasing apart maternal from fetal genetic effects and their relationships with long-term health outcomes.
Rokas, A. et al. Developing a theoretical evolutionary framework to solve the mystery of parturition initiation. eLife 9, e58343 (2020). A review article that presents the current understanding of the biological mechanisms of the timing of parturition and proposes theoretical models to further our understanding.
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This is a summary of: Solé-Navais, P. et al. Genetic effects on the timing of parturition and links to fetal birth weight. Nat. Genet. https://doi.org/10.1038/s41588-023-01343-9 (2023).
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New genetic loci associated with gestational duration show a complex link with birth weight. Nat Genet 55, 542–543 (2023). https://doi.org/10.1038/s41588-023-01344-8
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DOI: https://doi.org/10.1038/s41588-023-01344-8
