Resveratrol, Endocrine Disrupting Chemicals, Neurodegenerative Diseases and Depression: Genes, Transcription Factors, microRNAs, and Sponges Involved,Neurochemical Research

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Resveratrol, Endocrine Disrupting Chemicals, Neurodegenerative Diseases and Depression: Genes, Transcription Factors, microRNAs, and Sponges Involved
Neurochemical Research ( IF 3.7 ) Pub Date : 2022-10-16 , DOI: 10.1007/s11064-022-03787-7
Hai Duc Nguyen ₁

Affiliation

We aimed to examine the molecular basis of the positive effect of resveratrol against amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), cognitive impairment (CI), and depression induced by a mixture of bisphenol A (BPA), BPS, and BPF. The CTD, GeneMania, Metascape, SwissADME, Cytoscape, MIENTURNET, miRNAsong, and Autodock Vina were the fundamental tools for analysis. Resveratrol exerts its protective effects on selected diseases induced by a mixture of BPA, BPS, and BPF through the following genes: PTGS2 and GSR for ALS; INS, IL6, BDNF, and SOD1 for PD; BDNF, CASP3, TNF, INS, IGF1, IL1B for CI; and BDNF, PTGS2, and IL6 for depression. Detoxification was noted as the most important for ALS, dopamine metabolism for PD, apoptosis for CI, and the selenium micronutrient network for depression. hsa-miR-377-3p, hsa-miR-1-3p, hsa-miR-128-3p, and hsa-miR-204-5p were highlighted. We created and tested in silico sponges that inhibited these miRNAs. NFE2L2, BACH1, PPARG, and NR4A3 were listed as the key transcription factors implicated in resveratrol's protective effect against harmful studied chemicals. Furthermore, resveratrol's physicochemical properties and pharmacokinetics are consistent with its therapeutic benefits in ALS, PD, CI, and depression, owing to its high gastrointestinal absorption, drug-likeness, non-P-glycoprotein substrate, and capacity to penetrate the blood–brain barrier.

Graphical Abstract

中文翻译：

白藜芦醇、内分泌干扰物、神经退行性疾病和抑郁症：涉及的基因、转录因子、microRNA 和海绵

我们旨在研究白藜芦醇对双酚 A (BPA)、BPS 和 BPF 混合物诱发的肌萎缩侧索硬化症 (ALS)、帕金森病 (PD)、认知障碍 (CI) 和抑郁症的积极作用的分子基础. CTD、GeneMania、Metascape、SwissADME、Cytoscape、MIENTURNET、miRNAsong 和 Autodock Vina 是分析的基本工具。白藜芦醇通过以下基因对 BPA、BPS 和 BPF 的混合物诱导的特定疾病发挥保护作用：PTGS2 和 GSR 用于 ALS；INS、IL6、BDNF 和 SOD1 用于 PD；CI 的 BDNF、CASP3、TNF、INS、IGF1、IL1B；BDNF、PTGS2 和 IL6 用于治疗抑郁症。排毒被认为对 ALS 最重要，多巴胺代谢对 PD 最重要，细胞凋亡对 CI 最重要，硒微量营养素网络对抑郁症最重要。hsa-miR-377-3p、hsa-miR-1-3p、hsa-miR-128-3p、和 hsa-miR-204-5p 被突出显示。我们创建并测试了可抑制这些 miRNA 的电子海绵。NFE2L2、BACH1、PPARG 和 NR4A3 被列为关键转录因子，涉及白藜芦醇对有害研究化学品的保护作用。此外，白藜芦醇的理化性质和药代动力学与其在 ALS、PD、CI 和抑郁症中的治疗益处一致，这是由于其高胃肠道吸收、药物相似性、非 P-糖蛋白底物和穿透血脑屏障的能力.

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更新日期：2022-10-16

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