Drug Delivery and Translational Research ( IF 5.7 ) Pub Date : 2022-09-21 , DOI: 10.1007/s13346-022-01231-5 Lixiang Wang 1 , Hui Zhang 2
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In recent decades, the growing of the aging population in the world brings increasingly heavy burden of vision-threatening retinal diseases. One of the biggest challenges in the treatment of retinal diseases is the effective drug delivery to the diseased area. Due to the existence of multiple anatomical and physiological barriers of the eye, commonly used oral drugs or topical eye drops cannot effectively reach the retinal lesions. Innovations in new drug formulations and delivery routes have been continuously applied to improve current drug delivery to the back of the eye. Unique ocular anatomical structures or physiological activities on these ocular barriers, in turn, can facilitate drug delivery to the retina if compatible formulations or delivery routes are properly designed or selected. This paper focuses on key barrier structures of the eye and summarizes advances of corresponding drug delivery means to the retina, including various local drug delivery routes by invasive approaches, as well as systemic eye drug delivery by non-invasive approaches.
Graphical Abstract
中文翻译：
眼部屏障是一把双刃剑：防止和促进药物输送到视网膜
近几十年来，全球人口老龄化加剧，威胁视力的视网膜疾病负担日益沉重。治疗视网膜疾病的最大挑战之一是有效地将药物输送到患病区域。由于眼部存在多重解剖生理屏障，常用的口服药物或外用滴眼液不能有效到达视网膜病变部位。新药物配方和给药途径的创新不断得到应用，以改善目前眼球后部的药物给药。如果适当设计或选择相容的制剂或递送途径，这些眼屏障上独特的眼部解剖结构或生理活动反过来可以促进药物递送至视网膜。
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