Diabetes mellitus is a chronic metabolic disease, posing a considerable threat to global public health. Treating systemic comorbidities has been one of the greatest clinical challenges in the management of diabetes. Diabetic bladder dysfunction, characterized by detrusor overactivity during the early stage of the disease and detrusor underactivity during the late stage, is a common urological complication of diabetes. Oxidative stress is thought to trigger hyperglycaemia-dependent tissue damage in multiple organs; thus, a growing body of literature has suggested a possible link between functional changes in urothelium, muscle and the corresponding innervations. Improved understanding of the mechanisms of oxidative stress could lead to the development of novel therapeutics to restore the redox equilibrium and scavenge excessive free radicals to normalize bladder function in patients with diabetes.

糖尿病是一种慢性代谢性疾病，对全球公共卫生构成相当大的威胁。治疗系统性合并症一直是糖尿病管理中最大的临床挑战之一。糖尿病膀胱功能障碍是糖尿病常见的泌尿系统并发症，以疾病早期逼尿肌过度活动和晚期逼尿肌活动不足为特征。氧化应激被认为会在多个器官中引发高血糖依赖性组织损伤；因此，越来越多的文献表明尿路上皮、肌肉的功能变化和相应的神经支配之间可能存在联系。