A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury,Chemical Communications

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A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury
Chemical Communications ( IF 4.3 ) Pub Date : 2022-08-12 , DOI: 10.1039/d2cc04069g
Chuanhao Liu _{1,

2} , Lin Zhou ₂ , Ying Zheng ₂ , Huizi Man ₂ , Zhiwei Ye ₂ , Xinfu Zhang ₂ , Lijuan Xie ₁ , Yi Xiao ₂

Affiliation

We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (GA-Vis) was developed. With the aid of GA-Vis, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.

中文翻译：

用于监测早期酒精性肝损伤的高尔基体粘度转子

我们建议通过定量检测高尔基体粘度来监测酒精性肝损伤的早期阶段。因此，开发了第一个高尔基体靶向荧光转子（GA-Vis）。在GA-Vis的帮助下，通过活细胞和斑马鱼的荧光寿命成像定量评估酒精性肝损伤期间高尔基体粘度的变化。GA-Vis被认定为未来诊断酒精性肝损伤的实用工具。

更新日期：2022-08-12

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