A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury

Chuanhao Liu; Lin Zhou; Ying Zheng; Huizi Man; Zhiwei Ye; Xinfu Zhang; Lijuan Xie; Yi Xiao

doi:10.1039/D2CC04069G

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A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury†

Chuanhao Liu,

‡^ab Lin Zhou,‡^b Ying Zheng,^b Huizi Man,^b Zhiwei Ye,^b Xinfu Zhang,

^b Lijuan Xie*^a and Yi Xiao

*^b

Author affiliations

* Corresponding authors

^a Institute of Molecular Medicine & School of Biomedical Sciences, Huaqiao University, Quanzhou, China
E-mail: xielijuan@hqu.edu.cn

^b State key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
E-mail: xiaoyi@dlut.edu.cn

Abstract

We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (GA-Vis) was developed. With the aid of GA-Vis, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.

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Article information

DOI: https://doi.org/10.1039/D2CC04069G
Article type: Communication
Submitted: 21 Jul 2022
Accepted: 12 Aug 2022
First published: 12 Aug 2022

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Chem. Commun., 2022,58, 10052-10055

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A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury

C. Liu, L. Zhou, Y. Zheng, H. Man, Z. Ye, X. Zhang, L. Xie and Y. Xiao, Chem. Commun., 2022, 58, 10052 DOI: 10.1039/D2CC04069G

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Chemical Communications

A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury†

Abstract

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A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury

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