During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid shingomyelinase (ASM)-mediated membrane repair of gasdermin and perforin pores to delay cell death.

中文翻译：

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稍安毋躁！用 caspase-7 收紧毛孔

在感染过程中，成孔蛋白会迅速启动细胞裂解，但像上皮挤压这样的特殊过程需要额外的时间才能并行发生。在最近一期的Nature 杂志上，Nozaki 等人。(2022) 报告说，caspase-7 促进酸性鞘磷脂酶 (ASM) 介导的 gasdermin 和穿孔素孔的膜修复，从而延缓细胞死亡。