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Hold your horses! Reining in your fastest pores with caspase-7
Immunity ( IF 25.5 ) Pub Date : 2022-08-09 , DOI: 10.1016/j.immuni.2022.07.013
Jeffrey Y Zhou 1 , Katherine A Fitzgerald 1
Affiliation  

During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid shingomyelinase (ASM)-mediated membrane repair of gasdermin and perforin pores to delay cell death.



中文翻译:

稍安毋躁!用 caspase-7 收紧毛孔

在感染过程中,成孔蛋白会迅速启动细胞裂解,但像上皮挤压这样的特殊过程需要额外的时间才能并行发生。在最近一期的Nature 杂志上,Nozaki 等人。(2022) 报告说,caspase-7 促进酸性鞘磷脂酶 (ASM) 介导的 gasdermin 和穿孔素孔的膜修复,从而延缓细胞死亡。

更新日期:2022-08-09
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