Immunity

Immunity

Volume 55, Issue 8, 9 August 2022, Pages 1340-1342
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Hold your horses! Reining in your fastest pores with caspase-7

https://doi.org/10.1016/j.immuni.2022.07.013Get rights and content

During infection, pore-forming proteins rapidly initiate cell lysis, but specialized processes like epithelial extrusion need additional time to occur in parallel. In a recent issue of Nature, Nozaki et al. (2022) report that caspase-7 promotes acid shingomyelinase (ASM)-mediated membrane repair of gasdermin and perforin pores to delay cell death.

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Since the first descriptions of “apoptosis” in the 1970s, at least a dozen different modalities of programmed cell death have been described. Of these modalities, pore-forming cell death responses exhibit the fastest kinetics. For instance, inflammasomes are an emergency innate immune response initiated in response to pathogen- or damage-associated molecular patterns (PAMPs or DAMPs) characterized by inflammatory caspase-mediated cleavage of interleukin-1 (IL-1) family cytokines and

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The authors declare no competing interests.

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