Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide,Chemical Communications

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Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide
Chemical Communications ( IF 4.3 ) Pub Date : 2022-08-05 , DOI: 10.1039/d2cc01890j
Soei Watari ₁ , Hiroshi Inaba _{1,

2} , Tomonori Tamura ₃ , Arif Md Rashedul Kabir ₄ , Akira Kakugo _{4,

5} , Kazuki Sada _{4,

5} , Itaru Hamachi _{3,

6} , Kazunori Matsuura _{1,

2}

Affiliation

For light-induced stabilization of microtubules (MTs) to manipulate cells, a photo-reactive diazirine group was conjugated to a Tau-derived peptide, a motif binding on the inside of MTs. Ultraviolet (UV) light irradiation induced significant stabilization of MTs via the formation of a covalent bond of the peptide and showed toxicity.

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