Issue 66, 2022

Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide

Abstract

For light-induced stabilization of microtubules (MTs) to manipulate cells, a photo-reactive diazirine group was conjugated to a Tau-derived peptide, a motif binding on the inside of MTs. Ultraviolet (UV) light irradiation induced significant stabilization of MTs via the formation of a covalent bond of the peptide and showed toxicity.

Graphical abstract: Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide

Supplementary files

Article information

Article type
Communication
Submitted
02 Apr 2022
Accepted
25 Jul 2022
First published
05 Aug 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 9190-9193

Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide

S. Watari, H. Inaba, T. Tamura, A. Md. R. Kabir, A. Kakugo, K. Sada, I. Hamachi and K. Matsuura, Chem. Commun., 2022, 58, 9190 DOI: 10.1039/D2CC01890J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements