Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases,Chemical Communications

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Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases
Chemical Communications ( IF 4.3 ) Pub Date : 2022-08-01 , DOI: 10.1039/d2cc03644d
Xinye Wang ₁ , Zhixin Wang ₁ , Guoliang Zhu ₁ , Lan Jiang ₁ , Weiyan Zhang ₁ , Yiyi Huang ₁ , Zhanren Cong ₁ , Yi-Lei Zhao ₂ , Jian-He Xu ₁ , Tom Hsiang ₃ , Lixin Zhang ₁ , Qi Chen ₁ , Xueting Liu ₁

Affiliation

Fungal bifunctional terpene synthases (BFTSs) reportedly associate with a series of new skeletons of di/sesterterpenes. However, the molecular mechanisms underlying the variabilities in the ring system of BFTS-catalyzed products are not well understood. In this study, we identified a key site, S89/L89, that controls the conversion between bicyclic and polycyclic terpene skeletons catalyzed by two BFTSs, BsPS and FoFS. Our analysis revealed that a mutation on site 89 in the BFTSs alters the carbocation transportation pathway and redirects the competing reactions for previously unreported terpenes.

中文翻译：

真菌双功能萜烯合酶对双环和多环萜烯之间转化的化学控制

据报道，真菌双功能萜烯合酶 (BFTS) 与一系列新的二/酯萜骨架有关。然而，BFTS 催化产物的环系统变化背后的分子机制尚不清楚。在这项研究中，我们确定了一个关键位点 S89/L89，它控制由两种 BFTS、BsPS 和 FoFS 催化的双环和多环萜烯骨架之间的转化。我们的分析表明，BFTS 中 89 位点的突变改变了碳正离子的运输途径，并改变了以前未报道的萜烯的竞争反应。

更新日期：2022-08-01

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