Summary

This study includes 1005 men from the Gothenburg part of the Osteoporotic Fracture in Men Study (MrOS). Included are 66 men with anemia (hemoglobin < 130 g/L). The follow-up time was up to 16 years, and the main results are that anemia is associated with all fractures and non-vertebral osteoporotic fractures.

Introduction

Anemia and osteoporotic fractures are conditions that are associated with increased morbidity and mortality. Clinical studies have suggested that anemia can be used as a predictor of future osteoporotic fractures.

Method

Men from the Osteoporotic Fractures in Men Study (MrOS) Sweden, Gothenburg, with available hemoglobin (Hb) values (n = 1005, median age 75.3 years (SD 3.2)), were included in the current analyses. Of these, 66 suffered from anemia, defined as Hb < 130 g/L. Median follow-up time for fracture was 10.1 years and the longest follow-up time was 16.1 years.

Results

Men with anemia had, at baseline, experienced more falls and had a higher prevalence of diabetes, cancer, prostate cancer, hypertension, and stroke. Anemia was not statistically significantly associated with bone mineral density (BMD). Men with anemia had higher serum levels of fibroblast growth factor 23 (iFGF23) (p < 0.001) and phosphate (p = 0.001) and lower serum levels of testosterone (p < 0.001) and estradiol (p < 0.001). Moreover, men with anemia had an increased risk of any fracture (hazard ratio (HR) 1.97, 95% CI 1.28–3.02) and non-vertebral osteoporotic fracture (HR 2.15, 95% CI 1.18–3.93), after adjustment for age and total hip BMD, in 10 years. The risk for any fracture was increased in 10 and 16 years independently of falls, comorbidities, inflammation, and sex hormones. The age-adjusted risk of hip fracture was increased in men with anemia (HR 2.32, 95% CI 1.06–5.12), in 10 years, although this was no longer statistically significant after further adjustment for total hip BMD.

Conclusions

Anemia is associated with an increased risk for any fracture and non-vertebral osteoporotic fracture in elderly men with a long follow-up time. The cause is probably multifactorial and our results support that anemia can be used as a predictor for future fracture.

中文翻译：

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贫血与老年男性非椎骨骨质疏松性骨折风险增加有关：MrOS 瑞典队列

概括

这项研究包括来自男性骨质疏松性骨折研究 (MrOS) 哥德堡部分的 1005 名男性。其中包括 66 名患有贫血（血红蛋白 < 130 g/L）的男性。随访时间长达16年，主要结果是贫血与所有骨折和非椎体骨质疏松性骨折有关。

介绍

贫血和骨质疏松性骨折是与发病率和死亡率增加相关的疾病。临床研究表明，贫血可以用作未来骨质疏松性骨折的预测指标。

方法

来自瑞典哥德堡男性骨质疏松性骨折研究 (MrOS) 的男性，具有可用的血红蛋白 (Hb) 值（n  = 1005，中位年龄 75.3 岁 (SD 3.2)），被纳入当前分析。其中，66 人患有贫血，定义为 Hb < 130 g/L。骨折的中位随访时间为 10.1 年，最长随访时间为 16.1 年。

结果

在基线时，患有贫血的男性跌倒次数更多，糖尿病、癌症、前列腺癌、高血压和中风的患病率更高。贫血与骨矿物质密度 (BMD) 在统计学上没有显着相关性。贫血男性的成纤维细胞生长因子 23 (iFGF23) ( p  < 0.001) 和磷酸盐 ( p  = 0.001) 血清水平较高，而睾酮 ( p  < 0.001) 和雌二醇 ( p < 0.001)。此外，贫血男性发生任何骨折（风险比 (HR) 1.97，95% CI 1.28-3.02）和非椎体骨质疏松性骨折（HR 2.15，95% CI 1.18-3.93）的风险增加，调整了年龄和10 年内的全髋 BMD。任何骨折的风险在 10 年和 16 年内均有所增加，与跌倒、合并症、炎症和性激素无关。在 10 年内，患有贫血的男性髋部骨折的年龄调整风险增加（HR 2.32，95% CI 1.06–5.12），尽管在进一步调整全髋部 BMD 后这不再具有统计学意义。

结论

贫血与老年男性任何骨折和非椎骨骨质疏松性骨折的风险增加有关，随访时间长。原因可能是多因素的，我们的结果支持贫血可以用作未来骨折的预测因子。