Acne vulgaris is a universal multifactorial human skin condition of the pilosebaceous units. Although acne majorly prevails in teenagers, it is neither restricted to age group nor gender. Multifarious causative factors like Propionibacterium acnes, dysregulated sebum secretion, and androgens play an integral role in the manifestation of acne. Though abundant new chemical entities are convenient for acne therapy, none can treat this condition without compromising patient compliance. Furthermore, accessible treatment prevents the ailment and alleviates signs and symptoms with no absolute cure. So presently, despite the variety of topical formulations, the current market demands an ideal remedy to fulfill the unmet need for acne management. Extensive research has proved the upper hand of novel carrier systems over conventional formulations by substantially improving efficacy and eliminating unpleasant side effects. Lipid-based vesicular and particulate systems are promising prospects due to their closeness to the intrinsic structure of the skin, which offer delivery of the actives in a more desirable approach. This review underlines the practicability and superiority of liposomes, niosomes, transfersomes, ethosomes, cubosomes, solid lipid nanoparticles, and nanostructured lipid carriers over conventional therapies for acne. The review also highlights acne product market survey and available conventional as well as novel formulations portraying their scope in the market. In a nutshell, lipid-based vesicular and particulate systems prevail as a propitious modality for treating acne vulgaris as they conduce better penetrability, localized action, and reduce adverse effects. These systems have the ability to open a window of opportunities for effective acne alleviation.

中文翻译：

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脂质囊泡和颗粒载体介导的痤疮管理方法的见解。

寻常痤疮是一种普遍的多因素人类皮肤毛囊皮脂腺病症。虽然青春痘主要流行于青少年，但它并不局限于年龄段和性别。痤疮丙酸杆菌、皮脂分泌失调和雄激素等多种致病因素在痤疮的表现中起着不可或缺的作用。尽管大量的新化学实体便于治疗痤疮，但没有一种能够在不影响患者依从性的情况下治疗这种情况。此外，可获得的治疗可以预防疾病并减轻体征和症状，但没有绝对的治愈方法。因此，目前，尽管外用制剂多种多样，但当前市场需要一种理想的药物来满足未满足的痤疮管理需求。广泛的研究证明，新型载体系统通过显着提高功效和消除令人不快的副作用，比传统配方更具优势。基于脂质的囊泡和颗粒系统具有广阔的前景，因为它们与皮肤的内在结构非常接近，可以以更理想的方式提供活性成分。这篇综述强调了脂质体、脂质体、传递体、乙醇体、立方体、固体脂质纳米颗粒和纳米结构脂质载体相对于传统痤疮疗法的实用性和优越性。该评论还强调了痤疮产品市场调查和可用的常规以及描述其市场范围的新型配方。简而言之，基于脂质的囊泡和颗粒系统作为治疗寻常痤疮的有利方式而流行，因为它们具有更好的渗透性、局部作用并减少不良反应。这些系统能够打开有效缓解痤疮的机会之窗。