Semi-automated preparation of fine-needle aspiration samples for rapid on-site evaluation,Lab on a Chip

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Semi-automated preparation of fine-needle aspiration samples for rapid on-site evaluation
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-05-06 , DOI: 10.1039/d2lc00241h
Filipe Marques ₁ , Janosch Hauser ₁ , Emre Iseri ₁ , Igor Schliemann ₂ , Wouter van der Wijngaart ₁ , Niclas Roxhed _{1,

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Affiliation

Rapid on-site evaluation (ROSE) significantly improves the diagnostic yield of fine needle aspiration (FNA) samples but critically depends on the skills and availability of cytopathologists. Here, we introduce a portable device for semi-automated sample preparation for ROSE. In a single platform, the device combines a smearing tool and a capillary-driven chamber for staining FNA samples. Using a human pancreatic cancer cell line (PANC-1) and liver, lymph node, and thyroid FNA model samples, we demonstrate the capability of the device to prepare samples for ROSE. By minimizing the equipment needed in the operating room, the device may simplify the performance of FNA sample preparation and lead to a wider implementation of ROSE.

中文翻译：

用于快速现场评估的细针抽吸样本的半自动制备

快速现场评估 (ROSE) 显着提高了细针抽吸 (FNA) 样本的诊断率，但关键取决于细胞病理学家的技能和可用性。在这里，我们介绍了一种用于 ROSE 半自动样品制备的便携式设备。在单一平台中，该设备结合了涂抹工具和毛细管驱动的腔室，用于对 FNA 样品进行染色。我们使用人类胰腺癌细胞系 (PANC-1) 和肝脏、淋巴结和甲状腺 FNA 模型样本，展示了该设备为 ROSE 准备样本的能力。通过最大限度地减少手术室所需的设备，该设备可以简化 FNA 样品制备的性能，并导致 ROSE 的更广泛实施。

更新日期：2022-05-11

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