Experiences of racial discrimination have been shown to increase risk for alcohol problems. Some individuals may be particularly vulnerable to the negative effects of racial discrimination. However, little research has examined interaction effects between racial discrimination and individual characteristics, such as genetic predispositions and personality, in relation to alcohol outcomes. This study examined whether genetic risk and dimensions of impulsivity moderate the association between racial discrimination and alcohol problems among African American young adults (n = 383, M_age = 20.65, SD = 2.28; 81% female). Participants completed online surveys and provided a saliva sample for genotyping. Results from multiple regression analyses indicated that both blatant and subtle forms of racial discrimination (i.e., experience of racist events and racial microaggressions) were associated with more alcohol problems. Racial microaggressions interacted with dimensions of impulsivity in relation to alcohol problems, such that racial microaggressions were associated with more alcohol problems when negative urgency was high or when sensation seeking was low. There was no significant interaction between alcohol use disorder genome-wide polygenic score and experience of racist events or racial microaggression in relation to alcohol problems, which may partly reflect low power due in part to limited representation of African-Americans in genetic research. The findings highlight the need to increase the representation of African Americans in genetically-informed research in order to better characterize genetic risk and understand gene-environment interaction in this understudied population, as well as the importance of examining impulsivity as a multidimensional construct that interacts with racial discrimination in relation to alcohol outcomes.

种族歧视的经历已被证明会增加酒精问题的风险。有些人可能特别容易受到种族歧视的负面影响。然而，很少有研究检查种族歧视与个人特征（如遗传倾向和性格）之间与酒精结果相关的相互作用效应。这项研究检查了遗传风险和冲动的维度是否会调节非洲裔美国年轻人的种族歧视和酒精问题之间的关联（n  = 383，M_年龄 = 20.65，SD = 2.28; 81% 女性）。参与者完成了在线调查并提供了用于基因分型的唾液样本。多元回归分析的结果表明，公然和微妙的种族歧视形式（即，种族主义事件和种族微侵犯的经历）都与更多的酒精问题有关。种族微攻击与与酒精问题相关的冲动维度相互作用，因此当消极紧迫性高或感觉寻求低时，种族微攻击与更多的酒精问题相关。酒精使用障碍全基因组多基因评分与种族主义事件经历或与酒精问题相关的种族微攻击之间没有显着的相互作用，这可能部分反映了低权力，部分原因是非洲裔美国人在基因研究中的代表性有限。研究结果强调了增加非裔美国人在遗传知情研究中的代表性的必要性，以便更好地描述遗传风险并了解这一未充分研究的人群中的基因-环境相互作用，以及将冲动性作为与与与酒精结果有关的种族歧视。