Organic acidurias are inherited disorders that can severely affect mitochondria. A study in Caenorhabditis elegans suggests that binding of a toxic metabolite to a factor crucial for mitochondrial structure may contribute to disease mechanisms.

中文翻译：

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代谢物改变线粒体形状

有机酸尿症是一种遗传性疾病，会严重影响线粒体。一项针对秀丽隐杆线虫的研究表明，有毒代谢物与对线粒体结构至关重要的因子的结合可能有助于疾病机制。