Organic acidurias are inherited disorders that can severely affect mitochondria. A study in Caenorhabditis elegans suggests that binding of a toxic metabolite to a factor crucial for mitochondrial structure may contribute to disease mechanisms.
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References
Klecker, T. & Westermann, B. Open Biol. 11, 210238 (2021).
Mukherjee, I., Ghosh, M. & Meinecke, M. FEBS Lett. 595, 1159–1183 (2021).
Zhou, J. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-022-00883-2 (2022).
Zhou, J. et al. J. Cell Biol. 218, 580–597 (2019).
Wajner, M. & Goodman, S. I. J. Bioenerg. Biomembr. 43, 31–38 (2011).
Dimitrov, B. et al. J. Inherit. Metab. Dis. 44, 9–21 (2021).
Watson, E. et al. eLife 5, e17670 (2016).
Mun, J. Y. et al. J. Cell. Physiol. 224, 748–756 (2010).
Head, B. P. et al. Mol. Biol. Cell 22, 831–841 (2011).
Tarasenko, D. et al. J. Cell Biol. 216, 889–899 (2017).
Schwab, M. A. et al. Biochem. J. 398, 107–112 (2006).
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Klecker, T., Westermann, B. Mitochondrial shape alteration by metabolites. Nat Cell Biol 24, 410–412 (2022). https://doi.org/10.1038/s41556-022-00889-w
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DOI: https://doi.org/10.1038/s41556-022-00889-w