Enantioselective construction methods of chiral derivatives of α-tertiary amines using acyclic and cyclic trifluoromethylketimines are considered. The importance of a trifluoromethyl group in the structure of ketimine substrates for effective asymmetric addition of C-nucleophilic reagents in the presence of metal complex catalysts or organocatalysts is emphasized. The practical application of these chiral products in medicinal chemistry is covered.

中文翻译：

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基于含三氟甲基酮亚胺的手性 α-叔胺合成设计的现代方法：综述

考虑了使用无环和环状三氟甲基酮亚胺的 α-叔胺手性衍生物的对映选择性构建方法。强调了三氟甲基在酮亚胺底物结构中对于在金属络合物催化剂或有机催化剂存在下有效不对称加成 C-亲核试剂的重要性。涵盖了这些手性产品在药物化学中的实际应用。