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Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review

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Theoretical and Experimental Chemistry Aims and scope

Enantioselective construction methods of chiral derivatives of α-tertiary amines using acyclic and cyclic trifluoromethylketimines are considered. The importance of a trifluoromethyl group in the structure of ketimine substrates for effective asymmetric addition of C-nucleophilic reagents in the presence of metal complex catalysts or organocatalysts is emphasized. The practical application of these chiral products in medicinal chemistry is covered.

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Scheme 40

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Authors and Affiliations

  1. Institute of Organic Chemistry, NAS of Ukraine, Kyiv, Ukraine

    V. A. Sukach, V. M. Tkachuk & M. V. Vovk

  2. LLC Research and Production Enterprise “Enamine”, Kyiv, Ukraine

    V. A. Sukach

  3. Institute of Organic and Analytical Chemistry, University of Orleans, Orleans, France

    I. Gillaizeau

Authors
  1. V. A. Sukach
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  2. V. M. Tkachuk
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  3. I. Gillaizeau
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  4. M. V. Vovk
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Corresponding author

Correspondence to M. V. Vovk.

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Translated from Teoretychna ta Eksperymentalna Khimiya, Vol. 57, No. 6, pp. 333-355, November-December, 2021.

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Sukach, V.A., Tkachuk, V.M., Gillaizeau, I. et al. Modern Approaches to Synthetic Design of Chiral α-Tertiary Amines Based on Trifluoromethylcontaining Ketimines: A Review. Theor Exp Chem 57, 387–420 (2022). https://doi.org/10.1007/s11237-022-09710-z

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  • DOI: https://doi.org/10.1007/s11237-022-09710-z

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