As a key signaling molecule, cationic antimicrobial peptide LL37 helps mediate intracellular and extracellular signal transduction. It interacts with various cells facilitating tissue repair and plays a vital role in the defense against pathogens. LL37 acts as a broad-spectrum antimicrobial, possessing antitumor and antiviral properties. It promotes angiogenesis, co-operates with growth factors, antagonizes inflammatory media, participates in immune regulation, and helps tissue repair and growth. These biological effects are closely related to the information exchange between LL37 and various cells, in particular mesenchymal stem cells. Gaining a thorough understanding of the molecular mechanism of communication between LL37 and bone marrow-derived mesenchymal stem cells is crucial. However, work on tissue repair remains at an early stage. This paper reviews the main signal transduction mechanisms operating between LL37 and mesenchymal stem cells in bone and subsequent effects on cell proliferation, migration, and osteogenic differentiation.

作为关键的信号分子，阳离子抗菌肽 LL37 有助于介导细胞内和细胞外信号转导。它与促进组织修复的各种细胞相互作用，并在防御病原体中起着至关重要的作用。LL37 是一种广谱抗菌剂，具有抗肿瘤和抗病毒特性。它促进血管生成，与生长因子协同作用，拮抗炎症介质，参与免疫调节，帮助组织修复和生长。这些生物学效应与LL37与各种细胞，特别是间充质干细胞之间的信息交换密切相关。深入了解 LL37 与骨髓间充质干细胞之间的通讯分子机制至关重要。然而，组织修复工作仍处于早期阶段。