Background

In this study, the effects of long-term pregabalin use on the choroid and retinal nerve fiber layer were investigated in the fibromyalgia disease.

Methods

The patient group consisted of 41 fibromyalgia patients using pregabalin. The control group consisted of 41 newly diagnosed fibromyalgia patients who had not received any treatment yet. Choroidal and retinal nerve fiber layer thickness measurements were performed with Cirrus HD-OCT (Carl Zeiss Meditec Inc., Dublin, CA, USA) 30 minutes after pupil dilation with 1% tropicamide.

Results

There was no difference in subfoveal choroidal thickness, nasal choroidal thickness and temporal choroidal thickness between the patient and control groups (p > 0.05). Increasing the duration of drug use within the patient group was found to thin the retinal nerve fiber layer (p < 0.05).

Conclusion

We found that pregabalin had no effect on the choroid, while it had a thinning effect for retinal nerve fiber layer. It is recommended not to be preferred pregabalin in fibromyalgia patients with retinal nerve fiber layer damage such as diabetic retinopathy and glaucoma. Patients treated with pregabalin should have regular control in the ophthalmology clinic.

中文翻译：

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长期服用普瑞巴林治疗纤维肌痛会影响脉络膜和视网膜神经纤维层吗？

 背景

在这项研究中，研究了长期使用普瑞巴林对纤维肌痛疾病中脉络膜和视网膜神经纤维层的影响。

 方法

患者组由 41 名使用普瑞巴林的纤维肌痛患者组成。对照组由 41 名新诊断的纤维肌痛患者组成，尚未接受任何治疗。使用 1% 托吡卡胺散瞳 30 分钟后，使用 Cirrus HD-OCT（Carl Zeiss Meditec Inc.，Dublin，CA，USA）进行脉络膜和视网膜神经纤维层厚度测量。

 结果

患者与对照组的中心凹下脉络膜厚度、鼻脉络膜厚度和颞部脉络膜厚度没有差异（ p > 0.05）。研究发现，增加患者组的用药持续时间会使视网膜神经纤维层变薄。 p < 0.05）。

 结论

我们发现普瑞巴林对脉络膜没有影响，但对视网膜神经纤维层有变薄作用。对于糖尿病视网膜病变、青光眼等视网膜神经纤维层损伤的纤维肌痛患者，不建议首选普瑞巴林。接受普瑞巴林治疗的患者应在眼科诊所进行定期检查。