We read with interest the study of Bojarski et al conducted in non-coeliac disease patients suffering from all subtypes of irritable bowel syndrome (IBS) according to Rome 3 criteria. The investigators showed symptom improvement in 57% of patients with IBS following a gluten-free diet (GFD) over 2 months. Interestingly, improvement of symptoms as well as stool pattern was noted in all IBS subtypes.1 Further, the authors report poor specificity and sensitivity for endoscope-based confocal laser endomicroscopy (eCLE) for detecting wheat sensitivity, defined by the authors as symptomatic improvement on a GFD.1 Based on these observations, the authors advocate an 8-week trial of GFD in patients with IBS, irrespective of …

中文翻译：

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致编辑的信：共聚焦激光显微内镜对肠易激综合征患者小麦敏感性的前瞻性、双盲诊断多中心研究

我们感兴趣地阅读了 Bojarski 等人根据罗马 3 标准对患有所有肠易激综合征 (IBS) 亚型的非乳糜泻患者进行的研究。研究人员显示，57% 的 IBS 患者在 2 个月内无麸质饮食 (GFD) 后症状有所改善。有趣的是，在所有 IBS 亚型中都注意到症状和粪便模式的改善。1 此外，作者报告了基于内窥镜的共聚焦激光内镜 (eCLE) 检测小麦敏感性的特异性和敏感性差，作者将其定义为症状改善a GFD.1 基于这些观察，作者主张在 IBS 患者中进行为期 8 周的 GFD 试验，无论……