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  • Letter to the editor: prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome

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Letter
Letter to the editor: prospective, double-blind diagnostic multicentre study of confocal laser endomicroscopy for wheat sensitivity in patients with irritable bowel syndrome
  1. Lukas Michaja Balsiger1,
  2. Jan Tack1,2
  1. 1 Translational Research in Gastrointestinal Disorders, KU Leuven, Leuven, Belgium
  2. 2 Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium
  1. Correspondence to Prof. Jan Tack, Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium; jan.tack{at}kuleuven.be

https://doi.org/10.1136/gutjnl-2021-326252

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    We read with interest the study of Bojarski et al conducted in non-coeliac disease patients suffering from all subtypes of irritable bowel syndrome (IBS) according to Rome 3 criteria. The investigators showed symptom improvement in 57% of patients with IBS following a gluten-free diet (GFD) over 2 months. Interestingly, improvement of symptoms as well as stool pattern was noted in all IBS subtypes.1 Further, the authors report poor specificity and sensitivity for endoscope-based confocal laser endomicroscopy (eCLE) for detecting wheat sensitivity, defined by the authors as symptomatic improvement on a GFD.1 Based on these observations, the authors advocate an 8-week trial of GFD in patients with IBS, irrespective of …

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    Footnotes

    • Contributors JT and LMB contributed equally to drafting and revision of the manuscript.

    • Funding Supported by a Methusalem grant from KU Leuven to JT.

    • Competing interests None declared.

    • Patient and public involvement Patients and/or the public were not involved in the design, or conduct, or reporting, or dissemination plans of this research.

    • Provenance and peer review Not commissioned; internally peer reviewed.